Studies in the yeast Saccharomyces cerevisiae have validated the major features of the double‐strand break repair (DSBR) model as an accurate representation of the pathway through which meiotic crossovers (COs) are produced. This success has led to this model being invoked to explain double‐strand break (DSB) repair in other contexts. However, most non‐crossover (NCO) recombinants generated during S. cerevisiae meiosis do not arise via a DSBR pathway. Furthermore, it is becoming increasingly clear that DSBR is a minor pathway for recombinational (...) repair of DSBs that occur in mitotically‐proliferating cells and that the synthesis‐dependent strand annealing (SDSA) model appears to describe mitotic DSB repair more accurately. Fundamental dissimilarities between meiotic and mitotic recombination are not unexpected, since meiotic recombination serves a very different purpose (accurate chromosome segregation, which requires COs) than mitotic recombination (repair of DNA damage, which typically generates NCOs). (shrink)

Juxtaposing Cherríe Moraga's Loving in the War Years and Luce Irigaray's Speculum of the Other Woman, I explore the ways that sex and race intersect to complicate an Irigarayan account of the relations between mother and daughter. Irigaray's work is an effective tool for understanding the disruptive and potentially healing desire between mothers and daughters, but her insistence on sex as primary difference must be challenged in order to acknowledge the intersectionality of sex and race. Working from recent work on (...) the psychoanalysis of race, I argue that whiteness functions as a master signifier in its own right, and as a means of differentiation between the light-skinned Moraga and her brown-skinned mother. Irigaray's concept of blood deepens Moraga's account of her healing and subversive return to her mother. The juxtaposition of Moraga, Irigaray, and contemporary psychoanalysis of race can allow for a necessary revision of Irigaray's psychoanalysis that acknowledges the ways in which sexual difference is indexed by race and sheds new light on her account of the mother–daughter relation. (shrink)

Rebecca Tuvel’s controversial “In Defense of Transracialism” has been criticized for a lack of engagement with critical race theory. Disengagement with salient material on race is a consistent feature of the philosophical conversation out of which it arises. In this article, I trace the origins of feminist philosophy’s disengaged and distorted view of “transracialism” and racial passing through the work of Janice Raymond, Christine Overall, and Cressida Heyes, and consider some of the relevant work on passing that is omitted in (...) the philosophy of “transracialism.” Finally, I offer methodological suggestions to avoid such distortions and omissions in feminist philosophy. (shrink)

Although race mixing is often treated as a marginal matter or a transgression against dominant racial logic, this article argues that mixed-race bodies and interracial sexuality are central to the invention of whiteness and the origin of the white settler state in several ways. Race mixing is at the foundation of the modern conception of race; at the material and political origin of the white settler state; and serves as the grounding against which cultural and legal categories of race are (...) articulated. The conceptual history of race looks to mixed-race bodies as the means to define race and delimit races. The colonization and economic success of the white settler state in the United States depended on mixed-race individuals who served as emissaries and interpreters, while interracial sexuality was central to the economy of slavery. Dominant conceptions of whiteness, and of the identity of the white settler state, rely on the scrutiny of mixed bodies as a means of racial demarcation. Mixed race histories and subjects are of central interest to studies of the invention of whiteness and processes of racialization. (shrink)

An interdisciplinary and contemporary response to Irigaray’s work.

Drawing upon two independent national samples of 201 and 241 psychology graduate students, this article describes the development and psychometric evaluation of 4 Web-based student self-report scales tapping student socialization in the responsible conduct of research (RCR) with human participants. The Mentoring the Responsible Conduct of Research Scale (MRCR) is composed of 2 subscales assessing RCR instruction and modeling by research mentors. The 2 subscales of the RCR Department Climate Scale (RCR-DC) assess RCR department policies and faculty and student RCR (...) practices. The RCR Preparedness scale (RCR-P) and the RCR Field Integrity scale (RCR-FI) measure respectively students' confidence in their ability to conduct research responsibly and their belief in the RCR integrity of psychology as a discipline. Factor analysis, coefficient alphas, correlations, and multiple regression analyses demonstrated each of the scales had good internal consistency and concurrent and construct validity. (shrink)

Obesity is a public health problem in the United States. Experts have identified the regulation of food marketing as a policy strategy to address obesity and poor nutrition. However, the First Amendment can be a barrier to reducing exposure to problematic food marketing. In recent years, courts have become increasingly protective of speech, and particularly of “commercial speech,” or advertising, which can make it more difficult to regulate certain marketing practices.

This volume is fourth in the series of annuals created under the auspices of The Association for Feminist Ethics and Social Theory (FEAST). The topics covered herein-from peacekeeping and terrorism, to sex trafficking and women's paid labor, to poverty and religious fundamentalism-are vital to women and to feminist movements throughout the world.

This volume is fourth in the series of annuals created under the auspices of The Association for Feminist Ethics and Social Theory . The topics covered herein_from peacekeeping and terrorism, to sex trafficking and women's paid labor, to poverty and religious fundamentalism_are vital to women and to feminist movements throughout the world.

L'article analyse Vinfluence des émotions et de la rhétorique dans le raisonnement pratique. Suivant Aristote, on souligne ici le rôle essentiel des émotions dans les décisions et les actions, mais il est extrêmement ambivalent. La première partie (I.) présente la relation problématique entre la philosophie et le raisonnement rationnel d'une part et la rhétorique et les émotions de Vautre. Ensuite on analysera les arguments d'Aristote dans sa Rhétorique contre (II) et pour (III.) l'excitation des émotions dans les discours politiques. La (...) dernière partie (IV.) suggère deux éléments de discussion: comment et pourquoi la conception aristotélicienne des émotions pourrait-elle apporter une contribution dans le débat contemporain sur les émotions ? Car, d'une part, celui-ci est marqué par l'approche cognitiviste qui néglige la dimension sociale des émotions.D'autre part, la thèse aristotélicienne remet en question notre conception J'animai rationale et engage une nouvelle appréciation de la composante émotionnelle de la nature humaine. The paper investigates the impact of emotion and rhetoric for practical reasoning. With regard to Aristotle's theory of emotion, it is argued for the thesis that the role of emotion is essential for acting and decision making, but highly ambivalent in character. The first part (I.) presents the thesis and discuss the problematic relationship between philosophy and rational reasoning on the one side and rhetoric and emotional arousal on the other. The next two parts analyse Aristotle's arguments presented in his Rhetoric against (II.) and for (III.) arousal of emotions in political speech. The last part (IV.) outlines two arguments : how and why the Aristotelian account of emotion can add to contemporary philosophical discussion of emotions ? First, as the current debate on emotion is strongly shaped by a cognitivistic approach focusing on the cognitive requisites of emotion, the Aristotelian theory brings back in the political and social dimension of emotion, which has been neglected in current research. Second, the Aristotelian account of emotion challenges our self-conception as animal rationale and requires a reevaluation and recognition of the emotional components of human nature. (shrink)

Sabrina Fortin | : La recherche sur les populations permet d’améliorer nos conditions de vie en identifiant les facteurs de risque attribuables aux liens entre l’environnement et certains déterminants socio-sanitaires. Elle nécessite de vastes échantillons qui proviendront souvent de renseignements personnels ou de matériel biologique déjà recueillis. Pour les utiliser, la règle générale veut qu’un consentement individuel soit obtenu. Cependant, dans la pratique, il est souvent impossible d’obtenir un tel consentement sans affecter la qualité et la capacité de généralisation (...) des résultats de recherche. Cette obligation de consentement est fondée sur la primauté de la personne et la dignité humaine, qui ont été intégrées dans le droit des personnes à la fin de la Seconde Guerre mondiale. Ce principe fondamental a également été inséré au coeur de l’encadrement de la recherche scientifique. La philosophie personnaliste en serait à l’origine. Cet article, après avoir établi la provenance philosophique et historique du principe de dignité humaine, tente de rétablir un certain équilibre entre les intérêts individuels et collectifs impliqués dans la recherche populationnelle. | : According to this paper, personalist philosophy could be at the origin of the importance given to consent in an actual research normative framework. The obligation of consent is well established in Canadian law, but when the time comes to apply it to research on populations, which involves large number samples, it causes some impracticabilities. Access to personal data for populational research should be viewed as a common good contributing to improve life conditions. Hence, the collective interests generated by populational research should be better balanced against preferences and personal interests. (shrink)

BackgroundWith the emergence of Brain Computer Interfaces, clinicians have been facing a new group of patients with severe acquired brain injury who are unable to show any behavioral sign of consciousness but respond to active neuroimaging or electrophysiological paradigms. However, even though well documented, there is still no consensus regarding the nomenclature for this clinical entity.ObjectivesThis systematic review aims to 1) identify the terms used to indicate the presence of this entity through the years, and 2) promote an informed discussion (...) regarding the rationale for these names and the best candidates to name this fascinating disorder.MethodsThe Disorders of Consciousness Special Interest Group of the International Brain Injury Association launched a search on Pubmed and Google scholar following PRISMA guidelines to collect peer-reviewed articles and reviews on human adults published in English between 2006 and 2021.ResultsThe search launched in January 2021 identified 4,089 potentially relevant titles. After screening, 1,126 abstracts were found relevant. Finally, 161 manuscripts were included in our analyses. Only 58% of the manuscripts used a specific name to discuss this clinical entity, among which 32% used several names interchangeably throughout the text. We found 25 different names given to this entity. The five following names were the ones the most frequently used: covert awareness, cognitive motor dissociation, functional locked-in, non-behavioral MCS and higher-order cortex motor dissociation.ConclusionSince 2006, there has been no agreement regarding the taxonomy to use for unresponsive patients who are able to respond to active neuroimaging or electrophysiological paradigms. Developing a standard taxonomy is an important goal for future research studies and clinical translation. We recommend a Delphi study in order to build such a consensus. (shrink)

Ce numéro de la revue CORPUS est consacré au domaine berbère, l’une des branches de la famille afro-asiatique, et en particulier à la constitution et aux usages de corpus en linguistique berbère. Certains aspects de la structure grammaticale des langues berbères ainsi que de leur diversité étant encore peu connus, l’objectif général de ce volume est de faire progresser notre connaissance de la (micro)variation dans la famille berbère. Tout d’abord, il importe de garder à l’esprit que les lang...

The paper focuses on Rufinus’ translation of Eusebius’ Historia Ecclesiastica 1, 1-3, which discusses trinitarian and christological matters. Firstly, I will analyze how Rufinus amends or removes statements which are close to Origenism and Arianism, sometimes replacing them with orthodox ones; I will then examine Rufinus’ way of citing and interpreting the Bible, by correcting Eusebius’ reading, when it is suspected of heresy, or by explaining passages himself. This work of emendation reveals, on the one hand, Rufinus’ desire to give (...) the readers a text which fits perfectly with the nicen-constantinopolitan creed, and, on the other hand, his aim of protecting himself from accusations. (shrink)

Audrey Ghali-Lachapelle et Sabrina Maiorano.

L ’ article analyse l ’ influence des émotions et de la rhétorique dans le raisonnement pratique. Suivant Aristote, on souligne ici le rôle essentiel des émotions dans les décisions et les actions, mais il est extrêmement ambivalent. La première partie (I.) présente la relation problématique entre la philosophie et le raisonnement rationnel d ’ une part et la rhétorique et les émotions de l ’ autre. Ensuite on analysera les arguments d ’ Aristote dans sa Rhétorique contre (II.) et (...) pour (III.) l ’ excitation des émotions dans les discours politiques. La dernière partie (IV.) suggère deux éléments de discussion : comment et pourquoi la conception aristotélicienne des émotions pourrait-elle apporter une contribution dans le débat contemporain sur les émotions? Car, d ’ une part, celui-ci est marqué par l ’ approche cognitiviste qui néglige la dimension sociale des émotions. D ’ autre part, la thèse aristotélicienne remet en question notre conception d ’animal rationale et engage une nouvelle appréciation de la composante émotionnelle de la nature humaine. (shrink)

Les accords de libre-échange, qu’il s’agisse des accords multilatéraux de l’OMC ou des accords bilatéraux de nouvelle génération, ne portent pas atteinte, en principe, au droit des parties contractantes de fixer, à travers leur réglementation nationale, leur propre niveau de protection de la santé, de l’environnement ou encore des consommateurs. Ce droit comprend logiquement le droit d’adopter des mesures restrictives du commerce sur le fondement de la précaution. Pourtant, en pratique, les accords de libre-échange imposent une forme de gouvernance réglementaire (...) – fondée sur une rationalité strictement économique – qui vient limiter les possibilités de faire valoir certaines approches de précaution dans les relations commerciales internationales. Cela apparaît tout particulièrement à travers l’examen, dans les accords de libre-échange conclu par l’Union européenne, des mécanismes applicables aux mesures sanitaires et phytosanitaires et des disciplines commerciales relatives à la coopération réglementaire. (shrink)

Résumé : L’actuel programme d’« Histoire et éducation à la citoyenneté » pour le 2e cycle du secondaire, portant sur l’histoire du Québec, a suscité depuis 2006 de nombreux commentaires dans les milieux intellectuels en raison de son contenu. Certains affirment que la transmission des grands événements historiques qui structurent la mémoire collective ou nationale y est inexistante, d’autres soutiennent qu’il doit favoriser le développement des compétences critiques et citoyennes, donc, l’autonomie de l’élève face à la mémoire collective ou nationale. (...) Quelle position les enseignants du secondaire occupent-ils dans ce débat ? Il est possible de le découvrir par l’entremise de la perception qu’ils se font du programme et de ses trois compétences. Abstract: The current program «History and Citizenship Education» for the second cycle of secondary education, on the Quebec history, raised many comments in intellectual circles because of its content since 2006. Some argue that the transmission of major historical events that shape the collective or national memory is non-existent, others argue that it should promote the development of critical thinking and citizenship skills, thus the autonomy of the student facing the memory collective or national. What position secondary teachers do they have in this debate? It’s findable out through the teachers perceptions about program and its three skills. (shrink)

RONQUILLO C, BOSCHMA G, WONG ST and QUINEY L. Nursing Inquiry 2011; 18: 262–275Beyond greener pastures: exploring contexts surrounding Filipino nurse migration in Canada through oral historyThe history of immigrant Filipino nurses in Canada has received little attention, yet Canada is a major receiving country of a growing number of Filipino migrants and incorporates Filipino immigrant nurses into its healthcare workforce at a steady rate. This study aims to look beyond the traditional economic and policy analysis perspectives of global migration (...) and beyond the push and pull factors commonly discussed in the migration literature. Through oral history, this study explores biographical histories of nine Filipino immigrant nurses currently working in British Columbia and Alberta, Canada. Narratives reveal the instrumental role of the deeply embedded culture of migration in the Philippines in influencing Filipino nurses to migrate. Additionally, the stories illustrate the weight of cultural pressures and societal constructs these nurses faced that first colored their decision to pursue a career in nursing and ultimately to pursue emigration. Oral history is a powerful tool for examining migration history and sheds light on nuances of experience that might otherwise be neglected. This study explores the complex connections between various factors motivating Filipino nurse migration, the decision-making process, and other pre-migration experiences. (shrink)

Irigaray raises the question of sexual difference. Yet there are moments at which Irigaray’s own pursuit of this question recapitulates the kind of universalism it is meant to combat. She remains ensconced in judgments that close down the attempt to think beyond sexual difference. The article pursues this line of thought particularly in relation to her figuring of Antigone, suggesting that there is a need to open up sexual difference so that it does not function as a universal discourse, but (...) is open to other kinds of difference, for example, racial difference. (shrink)

A broad exploration of Irigaray’s philosophy of life and living. Featuring a highly accessible essay from Irigaray herself, this volume explores her philosophy of life and living. Life-thinking, an important contemporary trend in philosophy and in women’s and gender studies, stands in contrast to philosophy’s traditional grounding in death, exemplified in the work of philosophers such as Socrates, Plato, and Schopenhauer. The contributors to Thinking Life with Luce Irigaray consider Irigaray’s criticisms of the traditional Western philosophy of death, including its (...) either-or dualisms and binary logic, as well as some of Irigaray’s “solutions” for cultivating life. The book is comprehensive in its analyses of Irigaray’s relationship to classical and contemporary philosophers, writers, and artists, and produces extremely fruitful intersections between Irigaray and figures as diverse as Homer and Plato; Alexis Wright, the First-Nations novelist of Australia; and twentieth-century French philosophers like Sartre, Badiou, Deleuze, and Guattari. It also develops Irigaray’s relationship to the arts, with essays on theater, poetry, architecture, sculpture, and film. “This is a very timely text; it places Irigaray scholarship in conversation with the lively field of feminist philosophies of life, and this is a really wonderful, fruitful match. The collection itself contains many marvelous pieces. Luce Irigaray’s essay is strong and pithy—she reiterates a number of her important ideas, in accessible language, and places them in the context of pertinent questions in feminism.” — Sabrina L. Hom, coeditor of Thinking with Irigaray. (shrink)

Tibetan Buddhist writings frequently state that many of the things we perceive in the world are in fact illusory, as illusory as echoes or mirages. In Twelve Examples of Illusion , Jan Westerhoff offers an engaging look at a dozen illusions--including magic tricks, dreams, rainbows, and reflections in a mirror--showing how these phenomena can give us insight into reality. For instance, he offers a fascinating discussion of optical illusions, such as the wheel of fire (the "wheel" seen when a torch (...) is swung rapidly in a circle), discussing Tibetan explanations of this phenomenon as well as the findings of modern psychology, and significantly clarifying the idea that most phenomena--from chairs to trees--are similar illusions. The book uses a variety of crystal-clear examples drawn from a wide variety of fields, including contemporary philosophy and cognitive science, as well as the history of science, optics, artificial intelligence, geometry, economics, and literary theory. Throughout, Westerhoff makes both Buddhist philosophical ideas and the latest theories of mind and brain come alive for the general reader. -/- "This delightful book offers a rich and satisfying philosophical feast to anyone interested in the phenomenon of illusion itself or in the Buddhist analysis of the human condition. Westerhoff draws together classical Buddhist scholarship, contemporary cognitive science and his own judicious philosophical reflection in a serious but refreshingly accessible engagement with the Buddhist tradition in the exploration of the role of illusion in our cognitive and emotional lives." Jay L. Garfield, author of Fundamental Wisdom of the Middle Way: Nagarjuna's Mulamadhyamakakarika -/- "Jan Westerhoff creatively juxtaposes an important Buddhist study of illusion with fascinating modern researches on illusory experiences, using the latter to illuminate the former. The result is a revealing account of the pervasiveness of illusion in our cognitive experience and the very structure of our cognitive apparatus. It brings to life the Buddhist discussion of illusion, making it relevant to our everyday experience instead of being high-minded intellectual exercises only." -/- Tao Jiang, author of Contexts and Dialogue: Yogacara Buddhism and Modern Psychology on the Subliminal Mind -/- "The twelve similes for the illusory nature of this world are very profound, and Westerhoff does them wonderful justice in this excellent book." -/- Robert Thurman, Jey Tsong Khapa Professor of Buddhist Studies, Columbia University. (shrink)

The "hard problem" of today's consciousness studies is subjective experience: understanding why some brain processing is accompanied by an experienced inner life. Recent scientific advances offer insights for understanding the physiological and chemical phenomenology of consciousness. But by leaving aside the internal experiential nature of consciousness in favor of mapping neural activity, such science leaves many questions unanswered. In Ontology of Consciousness, scholars from a range of disciplines -- from neurophysiology to parapsychology, from mathematics to anthropology and indigenous non-Western modes (...) of thought -- go beyond these limits of current neuroscience research to explore insights offered by other intellectual approaches to consciousness. These scholars focus their attention on such philosophical approaches to consciousness as Tibetan Tantric Buddhism, North American Indian insights, pre-Columbian Mesoamerican civilization, and the Byzantine Empire. Some draw on artifacts and ethnographic data to make their point. Others translate cultural concepts of consciousness into modern scientific language using models and mathematical mappings. Many consider individual experiences of sentience and existence, as seen in African communalism, Hindi psychology, Zen Buddhism, Indian vibhuti phenomena, existentialism, philosophical realism, and modern psychiatry. Some reveal current views and conundrums in neurobiology to comprehend sentient intellection. Contributors: Karim Akerma, Matthijs Cornelissen, Antoine Courban, Mario Crocco, Christian de Quincey, Thomas B. Fowler, Erlendur Haraldsson, David. J. Hufford, Pavel B. Ivanov, Heinz Kimmerle, Stanley Krippner, Armand J. Labbé, James Maffie, Hubert Markl, Graham Parkes, Michael Polemis, E Richard Sorenson, Mircea Steriade, Thomas Szasz, Mariela Szirko, Robert A.F. Thurman, Edith L.B. Turner, Julia Watkin, Helmut Wautischer. (shrink)

Dominique Royoux est Directeur du service Prospective et Coopérations territoriales et de l'agence des temps de grand Poitiers, président de l'association Tempo territorial. Propos recueillis par Sabrina Costanzo. On trouvera le sommaire de l'ensemble du dossier paru dans la revue Territoires ici. Les politiques temporelles se développent en France depuis une dizaine d'années : où en sont-elles aujourd'hui? Nous manquons de recul pour procéder à une véritable évaluation des politiques - Urbanisme – Nouvel article.

Theories in cognitive science, and especially cognitive neuroscience, often claim that parts of cognitive systems are reused for different cognitive functions. Philosophical analysis of this concept, however, is rare. Here, I first provide a set of criteria for an analysis of reuse, and then I analyse reuse in terms of the functions of subsystems. I also discuss how cognitive systems execute cognitive functions, the relation between learning and reuse, and how to differentiate reuse from related concepts like multi-use, redundancy, and (...) duplication of parts. Finally, I illustrate how my account captures the reuse of dynamical subsystems as unveiled by recent research in cognitive neurobiology. This recent research suggests two different evolutionary justifications for reuse claims. _1_ Introduction _2_ Criteria for Analyses of Reuse _3_ Use and Reuse _4_ The Reuse of Dynamical Systems in Cognitive Systems _5_ Conclusion. (shrink)

Moral philosophers agree that welfare matters. But they disagree about what it is, or how much it matters. In this vital new work, Wayne Sumner presents an original theory of welfare, investigating its nature and discussing its importance. He considers and rejects all notable theories of welfare, both objective and subjective, including hedonism and theories founded on desire or preference. His own theory connects welfare closely with happiness or life satisfaction. Reacting against the value pluralism that currently dominates moral philosophy, (...) he advances welfare as the only basic ethical value. He concludes by discussing the implications of this thesis for ethical and political theory. Written in clear, non-technical language, and including a definitive survey of other work in this area, Sumner's book is essential reading for moral philosophers, political theorists, and welfare economists. (shrink)

Using a simulated, two-party negotiation, we examined how characteristics of the actor, target, and situation affected deception. To trigger deception, we used an issue that had no value for one of the two parties (indifference issue). We found support for an opportunistic betrayal model of deception: deception increased when the other party was perceived as benevolent, trustworthy, and as having integrity. Negotiators’ goals also affected the use of deception. Individualistic, cooperative, and mixed dyads responded differently to information about the other (...) party’s trustworthiness, benevolence, and integrity when deciding to either misrepresent or leverage their indifference issue. Mixed dyads displayed opportunistic betrayal. Negotiators in all-cooperative and all-individualistic dyads used different information in deciding whether to leverage their indifference issues and used the same information (benevolence) differently in deciding whether to misrepresent the value of their indifference issue. (shrink)

We show that \\) cannot be proved with one typical application of \\) in an intuitionistic extension of \ to higher types, but that this does not remain true when the law of the excluded middle is added. The argument uses Kohlenbach’s axiomatization of higher order reverse mathematics, results related to modified reducibility, and a formalization of Weihrauch reducibility.